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Another condition which can result from the long term use of corticosteroids is adrenal necrosis of the hip joints, a very painful and serious condition that may require surgery. The long term use of corticosteroids may cause osteoporosis which can result in bone fractures. The prolonged use of corticosteroids can cause obesity, [growth steroids](https://www.worklife.hu/cegek/dianabol-dosage-guide-how-much-dbol-should-you-take-per-day/) retardation in children, and even lead to convulsions and psychiatric disturbances. Corticosteroids have many side effects that can be mild or serious. These corticosteroids also are used to suppress the immune system and prevent rejection in people who have undergone organ transplant as well as many other conditions.
This allows the body’s adrenal glands to resume normal cortisol production. It happens because the body’s natural production of cortisol has been suppressed or stopped completely. This increases the risk of ulcers or bleeding. Your doctor may recommend you to taper off corticosteroid use gradually rather than stopping abruptly. It can also increase the risk of life-threatening adrenal crises during illness or trauma.
This may necessitate an increase of corticosteroid dose when they are used in combination with these drugs. For this reason prednisone may not be very effective in people with liver disease because of a reduction in their ability to convert prednisone to prednisolone. Nausea, vomiting, and shock are the reported side effects of adrenal crisis. Fludrocortisone (Florinef), a synthetic mineralocorticoid has strong salt retaining effects with significant anti-inflammatory actions, and is used mostly for it's salt retaining capabilities. Some glucocorticoids also in addition to their anti-inflammatory actions have salt retaining properties but they are used mostly for their anti-inflammatory effects.
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